Open research projects

An innovative trend promoted by the unique capabilities of additive manufacturing techniques is about the “4D Printing” concept. It is actually the process by which assemblies and parts embodying smart materials are printed, they are therefore able to react to changes in their environment. As a new way of
thinking and manufacturing method, few is known about how to systematically bring such smart products ideas into reality.

The HERMES research project aims at introducing a general framework for designing 4D printed solutions. It delineates the research effort to be made so that designers are sufficiently empowered to design such smart products. The ultimate goal of HERMES is to extend current CAD systems capabilities to fully embrace 4D printing opportunities and the increase of reasoning capacities embedded in systems and matter.

Coordinator :
Frédéric DEMOLY
UTMB / ICB
frederic.demoly@utbm.fr

Collaborators :

• Le2i
• UTMB
• uB

It is a major insight of the preceding two centuries that one can use a geometrical language to study the solutions of a given set of polynomial equations with coefficients in an arbitrary field, such as the complex numbers or even in an arbitrary ring, such as the integers. The corresponding objects,
called algebraic varieties, are extremely rich and mysterious due to their
dual nature, geometric and arithmetic.
The driving force of the project is the use of the recent and powerful theory of motivic A1-homotopy introduced by Voevodsky to produce new, and study classical, invariants of algebraic varieties of both geometric and arithmetic nature.
The expected applications have a very wide range: advances in the understanding of Voevodsky’s theory, producing new knowledge in affine algebraic geometry, extending previously known computations of invariants for families of algebraic varieties, and improvement of our arithmetical knowledge of certain kinds of algebraic varieties.

Coordinator :
Frédéric DEGLISE
CNRS / IMB
frederic.deglise@u-bourgogne.fr

Collaborators :

• uB
• UFC
• CNRS
• LMB

Liver X receptors (LXRs) are oxysterol-activated nuclear receptors involved in the regulation of cholesterol homeostasis and in the control of inflammation.
The general goal of this project is to assess how modulation of fatty acid metabolism by LXRs affects macrophage functions in the context of cardio-metabolic diseases and auto-immune diseases with a specific emphasis on the secretion of pro- and anti-inflammatory lipid mediators and efferocytosis (clearance of apoptotic cells by macrophages).

Coordinator :
David MASSON
CHU Dijon, UMR 1231 LNC, EFS
david.masson@chu-dijon.fr

Collaborators :

• CHU Dijon
• uB
• University of Franche-Comté
• INSERM
• EFS

The islands have the advantage of being geographically well defined spaces, possessing their own particular ecosystems and well definable network of sites and landscape marks. As such, Kvarner archipelago (Croatia, northern Adriatic), has been chosen as the case-study region for the IATEKA project.
These islands are already in the focus of ongoing historical and archaeological research concentrated on the territories of two sites : Mirine-Fulfinum (island of Krk), occupied between 1st and 9th c. AD, and the city of Osor (island of Cres), occupied without interruption since the protohistoric oppidum to the present
day. This classical approach will be highly enriched and complemented by IATEKA project.

By combining the obtained data from archaeological, anthropological, palynological and more globally paleoenvironmental research, the main goal of this project is to find relevant markers that are likely to provide the elements for the renewed and unprecedented understanding of population dynamics and itsconsequence on the evolution of these islands natural and anthropic environments.

Coordinator :
Morana CAUSEVIC BULLY
UFC / Chrono-environnement
morana.causevic-bully@univ-fcomte.fr

Collaborators :

• ArTeHiS
• Biogeosciences
• DRASSM Marseille
• MDAA Besançon
• University of Franche-Comté
• uB
• CNRS
• Institute for Anthropology (Zagreb)
• University of Bradfort
• University of Padova

The possibility that climate change exacerbates the impact of invasive species at the expense of native ones is of major concern for Conservation biologists. The
team proposes to develop a multidisciplinary approach to examine the impact of increased temperature and temperature variability on two invertebrate invading
species in Burgundy (the spotted wing fly, Drosophila suzukii and the freshwater crustacean amphipod, Gammarus roeseli), and their «rival» native species D.
melanogaster and G. fossarum.

Coordinator :
Franck CEZILLY
uB / Biogéosciences
franck.cezilly@u-bourgogne.fr

Collaborators :

• Chrono-environnement
• CSGA
• uB
• CNRS

The project aims at deciphering the structural, enzymatic and biochemical properties of new Nitric oxides and to investigate their regulation and roles in selected algae. A special focus will be given to their involvement in algae growth, innate immunity and response to abiotic stresses.

Coordinator :
David WENDEHENNE
uB / Agroécologie
wendehen@inra.fr

Collaborators :

• uB
• AgroSup
• INRA

The key goal of SCUVIRA project is to build, on the current state-of-the-art, the next generation of Supercontinuum fibre-based sources in the mid-IR (1-15 ) and UV (200-400nm) ranges with characteristics tailored to end-user driven applications such as optical detection, spectroscopy, gas and chemical sensing, fluorescence imaging.

Coordinator :
Frédéric SMEKTALA
uB / ICB
frederic.smektala@u-bourgogne.fr

Collaborators :

• FEMTO-ST
• uB
• UFC
• CNRS

The CoILS project intends to use colloidal emitters for the demonstration of on-chip integrated fluorescent light sources. These colloidal light sources are expected to be a strategic low cost alternative to technologically demanding integrated light emitting diodes (LEDs).

Coordinator :
Jean-Claude WEEBER
uB / ICB
jean-claude.weeber@u-bourgogne.fr

Collaborators :

• uB
• CNRS

Food2C studies the way that foods are provided to urban consumers today. This multidisciplinary project compares food supply chain organizations in 3 cities in France and Vietnam. Mobilizing the foodshed approach, and considering the use of fermentation as a low-technology method of conservation, Food2C is looking to produce a proof of concept of a low energy local food system, which could be developed in France.

Coordinator :
Hai Vu PHAM
AgroSup Dijon / CESAER
hai-vu.pham@inra.fr

• Collaborators :
• AgroSup
• PAM
• CSGA
• CIRAD
• IPSARD
• FAVRI

Eating behaviour is a key determinant of human health and inappropriate behaviours can be at the origin of some of the major pathologies affecting the modern societies (obesity, cardiovascular diseases, diabetes). Among the biological factors known to influence eating behaviour, sensory perception (including the sense of taste) plays an important role. Taste perception varies strongly between individuals but the factors at the origin of this variability are not fully understood. For example, different events occurring at the vicinity of the taste receptors on the tongue could modulate taste perception.
The team has recently suggested that the microbiota at the surface of the tongue could be involved by controlling the taste compounds concentration in the lingual film (the biological material covering the tongue). The aim of this project is to evaluate the contribution of the oral (lingual) microbiota in taste.

Coordinator :
Eric NEYRAUD
INRA / CSGA
eric.neyraud@dijon.inra.fr

Collaborators :

• INRA
• AgroSup
• CGFL

GNETWORKS is an interdisciplinary project which will participate to the valorization of the huge amount of data that our society produces into an economic manna. The team will try to make it possible by ranking and organizing these data in order to extract relevant information which could be used by academic research, public institutions, or private companies in various domain such as human and social sciences (digging Wikipedia data), economy (digging world trade data from UN, OECD, WTO), and even health domain (digging omic data).

Coordinator :
José LAGES
CNRS / UTINAM
jose.lages@utinam.cnrs.fr

Collaborators :

• UTINAM
• University of Franche-Comté
• CNRS

Recent genetic studies formally implicate the brain in obesity pathology and pinpoint genes regulating synaptic plasticity. Rodent data consistently evidence synaptic plasticity in brain circuits controlling appetite. The team, having strong expertise in neuroscience and physiology, aims at identifying the value of this state-dependent plasticity within brain feeding circuits. Highresolution imaging and modern neuroscience research tools will be leveraged to elucidate how food is integrated in discrete ‘soft’ circuits at the meal scale. Behavioral effects of mealrelated changes in synaptic connection and neuroglial interaction will be fully examined.
Such new knowledge about intimate mechanisms of satiety might provide new ways to manage obesity and maladaptive eating behaviors.

Coordinator :
Alexandre BENANI
CNRS / CSGA
alexandre.benani@u-bourgogne.fr

Collaborators :

• CSGA
• INRA
• uB
• CNRS

Identifying the genetic cause of developmental anomalies of previously unknown etiology is the first step towards implementing diagnostic tests, understanding disease biological processes, and guiding tailored patient management.
The main challenges for clinical and molecular delineation of such disorders include access to and careful phenotyping of patients with similar extremely rare disorders, and the mastery of cutting-edge sequencing technologies for data production and interpretation.
This project will play a major role in the Medical Institute of Genomic Medicine and Immunotherapy, GIMI of Bourgogne Franche-Comté, and will contribute to the translational research in the context of the new French “France Genomics Medicine 2025”.

Coordinator :
Christel THAUVIN
uB / CHU Dijon / UMR 1231 LNC
christel.thauvin@chu-dijon.fr

Collaborators :

• CHU Dijon
• uB
• UMR 1231 LNC